Ganetespib
货号：
19432-25mg 基本售价：
9436.0 元 规格：
25 mg
产品信息
概述| 货号 | 19432-25mg |
| 描述 | Ganetespib is a resorcinol-based second generation inhibitor of heat shock protein 90 (Hsp90) that demonstrates an IC50 value of 4 nM in cells.1 It induces growth inhibition and apoptosis of both hematologic and solid tumor cells (EC50 values range from 2 to 20 nM).1,2 Ganetespib causes rapid degradation of Hsp90 client proteins, resulting in an irreversible commitment to apoptosis.3 It is effective in vivo, producing significant growth inhibition or regression in solid tumor and hematological xenograft models.2,3 |
| 别名 | STA-9090; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lin, T.-Y.,Bear, M.,Du, Z., et al. The novel HSP90 inhibitor STA-9090 exhibits activity against Kit-dependent and -independent malignant mast cell tumors. Exp.Hematol. 36(10), 1266-1277 (2008).
2.Proia, D.A. and Bates, R.C. Ganetespib and HSP90: Translating preclinical hypotheses into clinical promise. Cancer Res. 74(5), 1294-1300 (2014).
3.Jhaveri, K. and Modi, S. Ganetespib: Research and clinical development. OncoTargets and Therapy 8, 1849-1858 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 364.4 |
| 分子式 | C20H20N4O3 |
| CAS号 | 888216-25-9 |
| 稳定性 | ≥ 2 years |
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