Pemetrexed (sodium salt hydrate)
货号：
14269-100mg 基本售价：
9408.0 元 规格：
100 mg
产品信息
概述| 货号 | 14269-100mg |
| 描述 | Pemetrexed is pyrrotopyrimidine-based, multi-targeted antifolate with broad in vivo antitumor activity. Originally identified as a highly efficient substrate for folylpolyglutamate synthase, pemetrexed potently inhibits multiple folate-dependent enzymes involved in both purine and pyrimidine synthesis including thymidylate synthase (Ki = 109 nM), dihydrofolate reductase (Ki = 7 nM), glycinamide ribonucleotide formyltransferase (Ki = 9.3 μM), and aminoimidazole carboxamide ribonucleotide formyltransferase (Ki = 3.6 μM).1 Its antiproliferative activity has been demonstrated in a wide variety of solid tumors, including non-small cell lung, breast, mesothelioma, colorectal, pancreatic, gastric, bladder, cervix, and head and neck.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Shih, C.,Chen, V.J.,Gossett, L.S., et al. LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Research 57, 1116-1123 (1997).
2.Hanauske, A.R.,Chen, V.,Paoletti, P., et al. Pemetrexed disodium: A novel antifolate clinically active against multiple solid tumors. Oncologist 6, 363-373 (2001).
3.Wang, X.,Wang, Y.,Wang, Y., et al. Association of thymidylate synthase gene 3-untranslated region polymorphism with sensitivity of non-small cell lung cancer to pemetrexed treatment: TS gene polymorphism and pemetrexed sensitivity in NSCLC. Journal of Biomedical Science 20(5), (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 597.5 |
| 分子式 | C20H19N5O6 • 2Na [7H2O] |
| CAS号 | 357166-29-1 |
| 稳定性 | ≥ 2 years |
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