| 货号 | 5855/50 |
| 别名 | Ethyl 3-[[[(4-chlorophenyl)methyl][(5-nit |
| 供应商 | Tocris |
| 生物活性 | Rev-Erbα/β agonist (EC50 = 710 nM; Kd = 800 nM). Alters circadian locomotor activity and core clock hypothalamic gene expression in mice. Induces weight loss in diet-induced obese mice. Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 437.94 |
| 分子式 | C20H24ClN3O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Shinet al (2012) Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erbα. Bioorg.Med.Chem.Lett. 22 4413. PMID: 22633688. Soltet al (2012) Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature 485 62. PMID: 22460951. |