JZP 361 ( )
货号：
5851/50 基本售价：
9359.3 元 规格：
50 mg
产品信息
概述| 货号 | 5851/50 |
| 别名 | [4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl](1H-1,2,4-triazol-1-yl)methanone |
性能| 供应商 | Tocris |
| 生物活性 | Potent and selective reversible MAGL inhibitor (IC50 = 46 nM). Exhibits 35-fold and 150-fold higher selectivity over human FAAH and ABHD6, respectively (IC50 values are 1.79 and 7.24 μM, respectively). Displays affinity for H1 receptors (pA2 = 6.81). Exhibits no activity at cannabinoid receptors at 10 μM. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 405.88 |
| 分子式 | C22H20ClN5O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in ethanol |
| 参考文献 | Patelet al (2015) Loratadine analogues as MAGL inhibitors. Bioorg.Med.Chem.Lett. 25 1436. PMID: 25752982. |
