MP A08 ( )
货号：
5803/50 基本售价：
9359.3 元 规格：
50 mg
产品信息
概述| 货号 | 5803/50 |
| 别名 | 4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide; NSC 122314 |
性能| 供应商 | Tocris |
| 生物活性 | Selective ATP competitive sphingosine kinase 2 and 1 (SphK2/1) inhibitor (Ki values are 6.9 and 27 μM, respectively). Exhibits selectivity for SphK 1 and 2 over other kinases. Inhibits cellular S1P production and increases sphingosine and ceramide levels in vitro. Also induces mitochondrial-associated apoptosis. Reduces tumor growth in a human lung adenocarcinoma xenograft mouse model, by inducing apoptosis and suppressing angiogenesis. Cell permeable. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 519.64 |
| 分子式 | C27H25N3O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Pitmanet al (2015) A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties. Oncotarget 6 7065. PMID: 25788259. |
