| 货号 | 5802/50 |
| 别名 | Ethyl 2-[[3,4-dihydro-4-oxo-3-[3-(1-pyrro |
| 供应商 | Tocris |
| 生物活性 | ALDH1A1 inhibitor (IC50 = 4.6 μM; Ki = 300 nM). Exhibits selectivity for ALDH1A1 over eight other ALDH isoforms. Disrupts spheroid formation and reduces cell viability of ovarian cancer cells in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >97 % |
| 计算分子量 | 431.57 |
| 分子式 | C21H25N3O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Condelloet al(2015)β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids. Oncogene 34 2297. PMID: 24954508. Morgan and Hurley (2015) Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors. J.Med.Chem 58 1964. PMID: 25634381. |