| 货号 | 5799/50 |
| 别名 | 5-[[4-[2-(5-Ethyl-2-pyridinyl)-2-ox |
| 供应商 | Tocris |
| 生物活性 | Insulin sensitizer; enhances insulin sensitivity and lowers blood-glucose levels in diabetic mouse models. Inhibits mitochondria pyruvate carriers; increases mitochondrial respiration rates, leading to a reduction in expression of lipogenic enzymes. Suppresses gluconeogenesis and lipogenesis in primary hepatocytes. Exhibits low binding affinity and activity at PPARγ(EC50 = 23.7 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 370.42 |
| 分子式 | C19H18N2O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Colcaet al (2013) Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT) relationship to newly identified mitochondrial pyruvate carrier proteins. PLoS One 8 e61551. PMID: 23690925. Divakaruniet al (2013) Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc.Natl.Acad.Sci.U.S.A. 110 5422. PMID: 23513224. Chenet al (2012) Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione. J.Biol.Chem. 287 23537. PMID: 22621923. |