| 货号 | 5747/50 |
| 别名 | 3-(2-Methyl-5-nitroimidazol-1-yl)-N |
| 供应商 | Tocris |
| 生物活性 | Cdc20 inhibitor; inhibits Cdc20-substrate interaction. Blocks substrate-mediated Cdc20 loading onto the anaphase-promoting complex (APC). Inhibits APC-dependent ubiquitylation. Prolongs mitotic duration in RPE1 cells in combination with proTAME (prodrug of TAME (Cat.No. 4506)) in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 438.65 |
| 分子式 | C13H14Cl3N7< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Wanget al (2015) Targeting Cdc20 as a novel cancer therapeutic strategy. Pharmacol.Ther. 151 141. PMID: 25850036. Sacktonet al (2014) Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. Nature 514 646. PMID: 25156254. |