| 货号 | 5179/50 |
| 别名 | 4,5,6,7-Tetrachloro-1H-Indene-1,3(2 |
| 供应商 | Tocris |
| 生物活性 | Selective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor (IC50 = 0.6 μM). Exhibits >100-fold selectivity for UCH-L3 over UCH-L1. Diminishes glycine transporter GlyT2 ubiquitination in brain stem and spinal cord primary neurons. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 283.92 |
| 分子式 | C9H2Cl4O2 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | de Juan-Sanzet al (2013) Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. PLoS ONE 8 e58863. PMID: 23484054. Liuet al (2003) Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem.Biol. 10 837. PMID: 14522054. |