| 货号 | 2097/50 |
| 别名 | 4-[[4-(4-Chlorophenyl)-2-thiazolyl] |
| 供应商 | Tocris |
| 生物活性 | Selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 μM); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro(IC50 = 0.9 - 4.6 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 302.78 |
| 分子式 | C15H11ClN2OS |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 312636-16-1 |
| 参考文献 | Frenchet al (2006) Antitumor activity of sphingosine kinase inhibitors. J.Pharmacol.Exp.Ther. 318 596. PMID: 16632640. Frenchet al (2003) Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 635862. |