| 货号 | 3107/50 |
| 别名 | N-methyl-N-[3-[4-(phenylmethyl)phen |
| 供应商 | Tocris |
| 生物活性 | Potent and selective inhibitor of LTA4 hydrolase. Does not inhibit other enzymes of the arachidonic acid cascade including COX-1, COX-2, LTC4 synthase and 5-lipoxygenase. Potently inhibits LTB4 production in whole blood (IC50 = 49 nM). Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 363.88 |
| 分子式 | C20H25NO3.HCl |
| 可溶性/溶解性 | Soluble to 25 mM in water and to 100 mM in DMSO |
| CAS号 | 423169-68-0 |
| 参考文献 | Askonaset al (2002) Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A4 hydrolase I: in vitro studies. J.Pharmacol.Exp.Ther. 300 577. PMID: 11805219. Kachuret al (2002) Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A4 hydrolase II: in vivo studies. J.Pharmacol.Exp.Ther. 300 583. PMID: 11805220. Penninget al (2002) Synthesis of potent leukotriene A4 hydrolase inhibitors. Identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid. J.Med.Chem. 45 3482. PMID: 12139459. |