| 货号 | 2009/50 |
| 别名 | 4-(2,3,6,7-Tetrahydro-2,6-dioxo-1-p |
| 供应商 | Tocris |
| 生物活性 | Highly selective, water-soluble, human A2B adenosine receptor antagonist. Ki values are 53.4, > 10000 and > 10000 nM at human A2B, A1 and A3 receptors respectively. Also selective versus rat A1 and A2A receptors (Ki values are 2200 and 24000 nM respectively). Produces potent analgesic effects in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 350.35 |
| 分子式 | C14H14N4O5S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in water with gentle warming |
| CAS号 | 409344-71-4 |
| 参考文献 | Abo-Salemet al (2004) Antinociceptive effects of novel A2B adenosine receptor antagonists. J.Pharmacol.Exp.Ther. 308 358. PMID: 14563788. Yan and Muller (2004) Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability. J.Med.Chem. 47 1031. PMID: 14761205. Hayallahet al (2002) 1,8-Disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists. J.Med.Chem. 45 1500. PMID: 11906291. Mulleret al (1998) 8-(Sulfostyryl)xanthines: water-soluble A2A-selective adenosine receptor antagonists. Bioorg.Med.Chem. 6 707. PMID: 9681137. |