| 货号 | 2768/50 |
| 别名 | N-(5-Chloro-2-methoxyphenyl)-N'-(2-m |
| 供应商 | Tocris |
| 生物活性 | Insulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC50 value of 12 μM. Inhibits growth of MCF-7 breast cancer cells in vitroandin vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 341.79 |
| 分子式 | C18H16ClN3O2 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 25 mM in ethanol |
| CAS号 | 196868-63-0 |
| 参考文献 | Sivakumaret al (2009) Autocrine loop for IGF-I receptor signaling in SLUG-mediated epithelial-mesenchymal transition. 34 329. PMID: 19148466. Andersonet al (2006) Parallel synthesis of diarylureas and their evaluation as inhibitors of insulin-like growth factor receptor. J.Comb.Chem. 8 784. PMID: 16961415. Gableet al (2006) Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth. Mol.Cancer 51079. |