| 货号 | 4996/50 |
| 别名 | 4-(2-Benzothiazolyl)-4-hydroxy-2,5- |
| 供应商 | Tocris |
| 生物活性 | Putative inhibitor of the thioredoxin-thioredoxin reductase (Trx-TrxR) system. Shown to inhibit Trx and induce a G1/S block in HT29 cells; inhibits cell proliferation in various colorectal cancer cell lines and MCF7 cells. Also elicits an anti-inflammatory response in A549 cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 243.28 |
| 分子式 | C13H9NO2S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Callisteret al (2008) PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-κB-dependent proinflammatory activation of alveolar epithelial cells. Br.J.Pharmacol. 155 661. PMID: 18587424. Mukherjeeet al (2007) A cellular and molecular investigation of the action of PMX464, a putative thioredoxin inhibitor, in normal and colorectal cancer cell lines. Br.J.Pharmacol. 151 1167. PMID: 17572693. Mukherjeeet al (2005) Cytotoxic and antiangiogenic activity of AW464 (NSC 706704), a novel thioredoxin inhibitor: an in vitro study. Br.J.Cancer 92 350. PMID: 15655539. |