PF 05175157 (50 MG)
货号：
5790/50 基本售价：
9359.3 元 规格：
50 mg
产品信息
概述| 货号 | 5790/50 |
| 别名 | 1,4-Dihydro-1'-[2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-spiro[5H-indazole-5,4'-piperidin]-7(6H)-one |
性能| 供应商 | Tocris |
| 生物活性 | Acetyl-CoA carboxylase (ACC) 2 and 1 inhibitor (IC50 values are 45 and 98 nM, respectively). Reduces hepatic and skeletal muscle malonyl-CoA levels in rats. Also inhibits hepatic de novo lipogenesis and reduces whole body respiratory exchange ratio in rats. Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 405.49 |
| 分子式 | C23H27N5O2 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 20 mM in ethanol |
| 参考文献 | Griffithet al (2014) Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes. J.Med.Chem. 57 10512. PMID: 25423286. |
