| 货号 | 1401/50 |
| 别名 | 8-Hydroxy-2-methyl-4(3H)-quinazolin |
| 供应商 | Tocris |
| 生物活性 | Novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 176.17 |
| 分子式 | C9H8N2O2 |
| 可溶性/溶解性 | Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO |
| CAS号 | 90417-38-2 |
| 参考文献 | Delaneyet al (2000) Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. Clin.Cancer.Res. 6 2860. PMID: 10914735. Bowmanet al (1998) Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064. Br.J.Cancer. 78 1269. PMID: 9823965. Griffinet al (1998) Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). J.Med.Chem. 41 5247. PMID: 9857092. |