| 货号 | 4480/50 |
| 别名 | 3-[2-[4-(4-Fluorobenzoyl)-1-piperid |
| 供应商 | Tocris |
| 生物活性 | Selective 5-HT2A receptor antagonist (Ki = 22 nM for at 5-HT2 receptors). Exhibits no affinity for 5-HT1A, 5-HT1B or 5-HT1D receptors. Inhibits collagen-induced serotonin secretion and platelet aggregation; displays no effect on serotonin uptake by platelets. Shown to inhibit arterial thrombus formation, but not venous thrombosis, in rat models. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 436.91 |
| 分子式 | C21H25FN4O3< |
| 可溶性/溶解性 | Soluble to 10 mM in water with gentle warming and to 10 mM in DMSO with gentle warming |
| 参考文献 | Pawlaket al (1998) A potent 5-hydroxytryptamine receptor (5-HT2A) antagonist, DV-7028, delays arterial thrombosis development in rats. Thromb.Res. 90 259. PMID: 9700856. Shibanoet al (1992) Pharmacological profile of a new 5-hydroxytryptamine 2 receptor antagonist, DV-7028. Arch.Int.Pharmacodyn.Ther. 319 114. PMID: 1285670. |