| 货号 | 1028/50 |
| 别名 | 7-(Hydroxyimino)cyclopropa[b]chrome |
| 供应商 | Tocris |
| 生物活性 | hmGlu1 subtype-selective non-competitive antagonist (IC50 = 6.5 μM). Has no agonist or antagonist activity at hmGlu2, 4a, 5a, 7b, 8a or ionotropic receptors at concentrations of up to 100 μM. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 247.25 |
| 分子式 | C13H13NO4 |
| 可溶性/溶解性 | Soluble to 5 mM in ethanol and to 100 mM in DMSO |
| CAS号 | 179067-99-3 |
| 参考文献 | Litschiget al (1999) CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding. Mol.Pharmacol. 55 453. PMID: 10051528. Hermanset al (1998) Reversible and non-competitive antagonist profile of CPCCOEt at the human type 1α metabotropic glutamate receptor. Neuropharmacology 37 1645. PMID: 9886688. Annouraet al (1996) A novel class of antagonists for metabotropic glutamate receptors, 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylates. Bioorg.Med.Chem.Lett. 6763. |