| 货号 | 0448/50 |
| 别名 | N-Benzyloxycarbonyl-L-leucylnorleuc |
| 供应商 | Tocris |
| 生物活性 | Potent, cell-permeable inhibitor of the Ca2+-dependent protease, calpain. Prevents collagen- and thrombin-induced platelet aggregation, probably by blocking calpain induced phospholipase C and thromboxane synthase activation. Potent cathepsin L inhibitor. Recently shown to preferentially inhibit a subset of protein-tyrosine phosphatases. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 362.47 |
| 分子式 | C20H30N2O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 117591-20-5 |
| 参考文献 | Schoenwaelder and Burridge (1999) Evidence for a calpeptin-sensitive protein-tyrosine phosphatase upstream of the small GTPase Rho. J.Biol.Chem. 274 14359. PMID: 10318859. Mehdi (1991) Cell-penetrating inhibitors of calpain. TiBS 16 150. PMID: 1877091. Sasakiet al (1990) Inhibitory effect of di-and tripeptidyl aldehydes on calpains and cathepsins. J.Enzyme Inhib. 3 195. PMID: 2079636. Tsujinakaet al (1988) Synthesis of a new cell penetrating calpain inhibitor (calpeptin). Biochem.Biophys.Res.Commun. 153 1201. PMID: 2839170. |