BVT 948 (50 MG)
货号：
2176/50 基本售价：
9359.3 元 规格：
50 mg
产品信息
概述| 货号 | 2176/50 |
| 别名 | 4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione |
性能| 供应商 | Tocris |
| 生物活性 | Non-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC50 = 0.09 - 1.7 μM); displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo. Also inhibits several cytochrome P450 isoforms (IC50 < 10 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 241.25 |
| 分子式 | C14H11NO3 |
| 可溶性/溶解性 | Soluble to 50 mM in ethanol and to 50 mM in DMSO |
| CAS号 | 39674-97-0 |
| 参考文献 | Liljebriset al (2004) Oxidation of protein tyrosine phosphatases as a pharmaceutical mechanism of action: a study using 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione. J.Pharmacol.Exp.Ther. 309 711. PMID: 14747616. |
