| 货号 | 5512/50 |
| 别名 | 4-(1-Acetyl-4-piperidinyl)-N-(amino |
| 供应商 | Tocris |
| 生物活性 | Potent and selective NHE1 inhibitor (IC50 = 31 nM). Selective for NHE1 over NHE2 and NHE3. Prevents ischemic damage in an ischemia reperfusion injury isolated rat heart model ex vivo. Prevents phenylephrine-induced cardiomyocyte hypertrophy in vitro, and attenuates cardiac hypertrophy and left ventricular dysfunction postinfarction in rats. Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 392.8 |
| 分子式 | C16H19F3N4 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Kilićet al (2014) Early and transient sodium-hydrogen exchanger isoform 1 inhibition attenuates subsequent cardiac hypertrophy and heart failure following coronary artery ligation. J.Pharmacol.Exp.Ther. 351 492. PMID: 25216745. Huberet al (2012) Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat. J.Med.Chem. 55 7114. PMID: 22803959. |