| 货号 | 5737/50 |
| 别名 | N5,N6-bis(2-Fluorophenyl)-[1,2,5]ox |
| 供应商 | Tocris |
| 生物活性 | Mitochondrial protonophore uncoupler; uncouples oxidative phosphorylation in L6 myoblast mitochondria in vitro (EC50 = 270 nM). Does not depolarize the plasma membrane. Protects mice from acute renal ischemic-reperfusion injury. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 340.29 |
| 分子式 | C16H10F2N6 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Kenwoodet al (2015) Structure-activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers. Bioorg.Med.Chem.Lett. 25 4858. PMID: 26119501. Kenwoodet al (2013) Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol.Metab. 3 114. PMID: 24634817. |