| 货号 | 2292/50 |
| 别名 | 11-[[4-[4-(Diethylamino)butyl]-1-pi |
| 供应商 | Tocris |
| 生物活性 | High affinity, selective muscarinic M2 receptor antagonist (pKi values are 8.3, 7.7 and 6.82 for M2, M1 and M3 receptors, respectively). Displays cardioselectivity in vivo, over intestinal, tracheal and bladder muscarinic receptors; inhibits vagally and agonist-induced bradycardia. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 463.62 |
| 分子式 | C27H37N5O2 |
| 可溶性/溶解性 | Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 123548-16-3 |
| 参考文献 | Doodset al (1994) Pharmacological profile of selective muscarinic receptor antagonists on guinea-pig ileal smooth muscle. Eur.J.Pharmacol. 253 275. PMID: 8200421. Doodset al (1991) Cardioselectivity of AQ-RA 741, a novel tricyclic antimuscarinic drug. Eur.J.Pharmacol. 192 147. PMID: 2040358. Dorjeet al (1991) Antagonist binding profiles of five cloned human muscarinic receptor subtypes. J.Pharmacol.Exp.Ther. 256 727. PMID: 1994002. |