| 货号 | 2432/50 |
| 别名 | 6,7-Dichloro-1,5-dihydroimidazo[2,1 |
| 供应商 | Tocris |
| 生物活性 | Potent type III phosphodiesterase (PDE3) inhibitor (IC50 = 36 nM). Inhibits platelet aggregation and produces potent thrombocytopenic effects via inhibition of megakaryocyte maturation. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 292.55 |
| 分子式 | C10H7Cl2N3O.HCl |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| CAS号 | 58579-51-4 |
| 参考文献 | Wanget al (2005) Comparison of the biological activities of anagrelide and its major metabolites in haematopoietic cell cultures. Br.J.Pharmacol. 146 324. PMID: 16041400. Mazuret al (1992) Analysis of the mechanism of anagrelide-induced thrombocytopenia in humans. Blood 79 1931. PMID: 1562721. Gillespie (1988) Anagrelide: a potent and selective inhibitor of platelet cyclic AMP phosphodiesterase enzyme activity. Biochem.Pharmacol. 37 2866. PMID: 2456068. |