A01 (50 MG)
货号：
5397/50 基本售价：
9359.3 元 规格：
50 mg
产品信息
概述| 货号 | 5397/50 |
| 别名 | [4-[[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone |
性能| 供应商 | Tocris |
| 生物活性 | High affinity Smurf1 E3 ubiquitin ligase inhibitor (Kd = 3.7 nM). Attenuates Smurf1-mediated Smad 1/5 degradation and enhances BMP signaling. Potentiates BMP-2-induced osteoblastic activity in C2C12 myoblasts and MC3T3-E1 osteoblast precursor cells. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 512.93 |
| 分子式 | C22H20ClF3N4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Caoet al (2014) Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. Sci.Rep. 4 4965. PMID: 24828823. |
