| 货号 | 4845/50 |
| 别名 | 4-(2-Chlorophenoxy)-N-[3-[(methylam |
| 供应商 | Tocris |
| 生物活性 | Potent stearoyl-CoA desaturase 1 (SCD1) inhibitor (IC50 = 0.4 nM). Selective for SCD1 over a range of kinases and hERG channels. Inhibits proliferation of squamous cell carcinoma FaDu cells in vitro. Also induces cell death of undifferentiated human embryonic stem cells (ESCs). Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 387.86 |
| 分子式 | C20H22ClN3O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Ben-Davidet al (2013) Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell Stem Cell 12 167. PMID: 23318055. Xinet al (2008) Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors. Bioorg.Med.Chem.Lett. 18 4298. PMID: 18632269. |