| 货号 | 5460/50 |
| 别名 | 5-[3-Bromo-4-(dimethylamino)phenyl] |
| 供应商 | Tocris |
| 生物活性 | Allosteric inhibitor of glutaminase. Blocks Rho-GTPase-dependent transformation of fibroblasts. Suppresses breast cancer cell growth and invasive activity in vitro. Also inhibits P-493 B lymphoma cell growth and reduces tumor size of P-493 cell xenografts in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 475.42 |
| 分子式 | C27H27BrN2O |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Stalneckeret al (2015) Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells. Proc.Natl.Acad.Sci.U.S.A. 112 394. PMID: 25548170. Luet al (2010) Cancer metabolism: is glutamine sweeter than glucose? Cancer Cell 18 199. PMID: 20832746. Wanget al (2010) Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell 18 207. PMID: 20832749. |