| 货号 | 1073/50 |
| 别名 | (RS)-1-Amino-5-phosphonoindan-1-car |
| 供应商 | Tocris |
| 生物活性 | Rigidified analog of MPPG (Cat. No. 0853); selective group II metabotropic glutamate receptor antagonist (IC50 = 30 μM) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Increases extracellular glutamate concentrations and possesses unusual inverse agonist-like action. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 257.18 |
| 分子式 | C10H12NO5P |
| 可溶性/溶解性 | Soluble to 100 mM in 1.1eq. NaOH |
| 参考文献 | Xiet al (2002) Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens. J.Pharmacol.Exp.Ther. 300 162. PMID: 11752112. Krenzet al (2000) Group I, II and III mGluR compounds affect rhythm generation in the gastric circuit of the crustacean stomatogastric ganglion. J.Neurophysiol. 83 1188. PMID: 10712449. Maet al (1997) Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists. Bioorg.Med.Chem.Lett. 71195. |