Melittin
货号：
17494-5mg 基本售价：
9352.0 元 规格：
5 mg
产品信息
概述| 货号 | 17494-5mg |
| 描述 | Melittin is a small protein that is the principal cytotoxic component of venom of the honey bee, A. mellifera.1 Structurally, melittin consists of two α-helical segments forming a bent rod, with hydrophilic residues on the convex side and hydrophobic sites on the concave side.1,2 This allows melittin molecules to assemble as tetramers on membrane surfaces and form pores, resulting in cell death. Bee venom is also known to stimulate phospholipase A2(PLA2) activity, and this may be linked to melittin-mediated pore production as well as the presence of low molecular weight PLA2 enzymes in the venom.2,3 Melittin also has antimicrobial properties, which, combined with its cytolytic properties, extends its potential for therapeutic applications.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Terwilliger, T.C. and Eisenberg, D. The structure of melittin. II. Interpretation of the structure. The Journal of Biological Chemisty 257(11), 6016-6022 (1982).
2.Kourie, J.I. and Shorthouse, A.A. Properties of cytotoxic peptide-formed ion channels. American Journal of Physiology.Cell Physiology 278, C1063-C1087 (2000).
3.Moreno, M. and Giralt, E. Three valuable peptides from bee and wasp venoms for therapeutic and biotechnological use: Melittin, apamin and mastoparan. Toxins 7, 1126-1150 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 2846.5 |
| 分子式 | C131H229N39O31 |
| CAS号 | 37231-28-0 |
| 稳定性 | ≥ 2 years |
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