20-carboxy Arachidonic Acid
货号：
10007912-100ug 基本售价：
9226.0 元 规格：
100 ug
产品信息
概述| 货号 | 10007912-100ug |
| 描述 | 20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes containing recombinant human CYP4F3B.1 Like 20-HETE, 20-COOH-AA inhibits ion transport in the kidneys. It also produces vasorelaxation of porcine coronary microvessels constricted with endothelin. 20-COOH-AA binds to isolated ligand binding domains of peroxisome proliferator-activated receptor α (PPARα) (Kd = 0.87 ± 0.12 µM) and PPARγ (Kd = 1.7 ± 0.5 µM), and is a dual activator of PPARα and PPARγ in a transiently transfected COS-7 cell reporter system.1 |
| 别名 | 20-carboxy AA;20-COOH-AA; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Fang, X.,Dillon, J.S.,Hu, S., et al. 20-carboxy-arachidonic acid is a dual activator of peroxisome proliferator-activated receptors α and γ. Prostaglandins & Other Lipid Mediators 82, 175-184 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | >98% |
| 计算分子量 | 334.5 |
| 分子式 | C20H30O4 |
| CAS号 | 79551-84-1 |
| 稳定性 | ≥ 1 year |
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