Troglitazone
货号：
71750-100mg 基本售价：
9212.0 元 规格：
100 mg
产品信息
概述| 货号 | 71750-100mg |
| 描述 | Troglitazone is a TZD which was approved for the treatment of insulin resistance and hyperglycemia in Type II diabetes, under the trade name Resulin™, but was withdrawn from the market due to hepatotoxicity. Troglitazone is a potent and selective PPARγ agonist. The EC50 values for transactivation of human and mouse PPARγ in a cell-based assay are 0.55 and 0.78 µM, respectively.1 In the same assay system, no activation of PPARα and PPARδ was observed at concentrations up to 10 µM. Troglitazone binds to the PPARγ ligand-binding domain (LBD) but fails to induce interaction of the PPARγ LBD with the transcriptional coactivators SRC-1, TIF2, AIB1, p300, or TRAP220.2 Troglitazone also induces cell cycle arrest and apoptosis in several cancer cell lines with an EC50 of 10 µM.3 |
| 别名 | Resulin™; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Willson, T.M.,Brown, P.J.,Sternbach, D.D., et al. The PPARs: From orphan receptors to drug discovery. Journal of Medicinal Chemistry 43(4), 528-550 (2000).
2.Kodera, Y.,Takeyama, K.i.,Murayama, A., et al. Ligand type-specific interactions of peroxisome proliferator-activated receptor γ with transcriptional coactivators. The Journal of Biological Chemisty 275, 33201-33204 (2000).
3.Yoshizawa, K.,Cioca, D.P.,Kawa, S., et al. Peroxisome proliferator-activated receptor γ ligand troglitazone induces cell cycle arrest and apoptosis of hepatocellular carcinoma cell lines. Cancer 95(10), 2243-2251 (2002).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 441.5 |
| 分子式 | C24H27NO5S |
| CAS号 | 97322-87-7 |
| 稳定性 | ≥ 2 years |
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