Ozanimod
货号：
19922-25mg 基本售价：
9184.0 元 规格：
25 mg
产品信息
概述| 货号 | 19922-25mg |
| 描述 | Ozanimod is a selective, orally available modulator of the sphingosine-1-phosphate (S1P) receptors S1P1 and SIP5.1,2 It induces internalization of S1P1, decreases circulating B and CCR7(+) T lymphocytes, and reduces inflammation and disease parameters in three autoimmune disease models.1 Ozanimod is in clinical trials for relapsing multiple sclerosis and ulcerative colitis.1,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Scott, F.L.,Clemons, B.,Brooks, J., et al. Ozanimod (RPC1063) is a potent sphingosine-1-phosphate receptor-1 (S1P1 ) and receptor-5 (S1P5 ) agonist with autoimmune disease-modifying activity. Br.J.Pharmacol. 173(11), 1778-1792 (2016).
2.Subei, A.M., and Cohen, J.A. Sphingosine 1-phosphate receptor modulators in multiple sclerosis. CNS Drugs 29(7), 565-575 (2015).
3.Sandborn, W.J.,Feagan, B.G.,Wolf, D.C., et al. Ozanimod induction and maintenance treatment for ulcerative colitis. N.Engl.J.Med. 374(18), 1754-1762 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 404.5 |
| 分子式 | C23H24N4O3 |
| CAS号 | 1306760-87-1 |
| 稳定性 | ≥ 2 years |
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