| 货号 | 10675-500ug |
| 描述 | Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access.1 SAHA-BPyne is a SAHA derivative with a benzophenone crosslinker and an alkyne tag intended to be used for profiling HDAC activities in proteomes and live cells.2,3 Such terminal alkyne groups can be used in linking reactions, known as click chemistry, characterized by high dependability and specificity of azide-alkyne bioconjugation reactions.4,5 SAHA-BPyne labels HDAC complex proteins both in proteomes at 100 nM and in live cells at 500 nM and demonstrates an IC50 value of ~3 μM for inhibition of HDAC activity in HeLa cell nuclear lysates in an HDAC activity assay.2 |
| 别名 | Click Tag™ SAHA-BPyne;Suberoylanilide Hydroxamic Acid-BPyne; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Marks, P.A. and Breslow, R. Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drug. Nat. Biotechnol. 25(1), 84-90 (2007). 2.Salisbury, C.M. and Cravatt, B.F. Optimization of activity-based probes for proteomic profiling of histone deacetylase complexes. Journal of the American Chemical Society 130, 2184-2194 (2008). 3.Salisbury, C.M. and Cravatt, B.F. Activity-based probes for proteomic profiling histone of deacetylase complexes. Proceedings of the National Academy of Sciences of the United States of America 104(4), 1171-1176 (2011). 4.Kolb, H.C. and Sharpless, K.B. The growing impact of click chemistry on drug discovery. Drug Discovery Today 8(24), 1128-1137 (2003). 5.Lutz, J.F. and Zarafshani, Z. Efficient construction of therapeutics, bioconjugates, biomaterials and bioactive surfaces using azide-alkyne "click" chemistry. Advanced Drug Delivery Reviews 60, 958-970 (2008). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 477.6 |
| 分子式 | C27H31N3O5 |
| CAS号 | 930772-88-6 |
| 稳定性 | ≥ 1 year |
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