Rebeccamycin
货号：
17914-2.5mg 基本售价：
9142.0 元 规格：
2.5 mg
产品信息
概述| 货号 | 17914-2.5mg |
| 描述 | Rebeccamycin is an indolocarbazole antibiotic produced by S. aerocolonigenes ATCC39243 that weakly inhibits DNA topoisomerase I.1,2 It is cytotoxic to human lung adenocarcinoma, colon carcinoma, and nasopharyngeal carcinoma cell lines (IC50s range from 0.4-98 µM), producing single-strand breaks in the DNA of these tumor cells.3 |
| 别名 | BRN 4732638;NSC 359079; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Long, B.H.,Rose, W.C.,Vyas, D.M., et al. Discovery of antitumor indolocarbazoles: Rebeccamycin, NSC 655649, and fluoroindolocarbazoles. Curr.Med.Chem.Anticancer Agents 2, 255-266 (2002).
2.Sánchez, C.,Butovich, I.A.,Braña, A.F., et al. The biosynthetic gene cluster for the antitumor rebeccamycin: Characterization and generation of indolocarbazole derivatives. Chemistry & Biology 9(4), 519-531 (2002).
3.Bush, J.A.,Long, B.H.,Catino, J.J., et al. Production and biological activity of rebeccamycin, a novel antitumor agent. J.Antibiot.(Tokyo) 40(5), 668-678 (1987).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 570.4 |
| 分子式 | C27H21Cl2N3O7 |
| CAS号 | 93908-02-2 |
| 稳定性 | ≥ 2 years |
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