| 货号 | 16207-10mg |
| 描述 | Ingenol-3-angelate is a hydrophobic diterpene ester that can be isolated from the euphorb E. peplus. It rapidly induces cell death in proliferating keratinocytes through plasma membrane and mitochondrial disruption, although it can also initiate apoptosis in some cancer cell lines (LD90 = ~190 µM).1 Secondarily, ingenol-3-angelate causes inflammation due, at least in part, to activation of PKC, leading to antibody-dependent cellular cytotoxicity.2,3,4 These actions have relevance in diminishing actinic keratosis and, possibly, other cancers of the skin.5,6 |
| 别名 | Ingenol Mebutate;3-Ingenyl Angelate;PEP005;Picato®; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ogbourne, S.M.,Suhrbier, A.,Jones, B., et al. Antitumor activity of 3-ingenyl angelate: Plasma membrane and mitochondrial disruption and necrotic cell death. Cancer Research 64(8), 2833-2839 (2004). 2.Gillespie, S.K.,Zhang, X.D. and Hersey, P. Ingenol 3-angelate induces dual modes of cell death and differentially regulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in melanoma cells. Molecular Cancer Therapeutics 3(12), 1651-1658 (2004). 3.Li, L.,Shukla, S.,Lee, A., et al. The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature. Cancer Research 70(11), 4509-4519 (2010). 4.Hasler, C.M.,Acs, G. and Blumberg, P.M. Specific binding to protein kinase C by ingenol and its induction of biological responses. Cancer Research 52(1), 202-208 (1992). 5.Lebwohl, M.,Swanson, N.,Anderson, L.L., et al. Ingenol mebutate gel for actinic keratosis. New England Journal of Medicine 366(11), 1010-1019 (2012). 6.Micali, G.,Lacarrubba, F.,Nasca, M.R., et al. Topical pharmacotherapy for skin cancer. Part I. Pharmacology. J.Am.Acad.Dermatol. 70(6), 965.e961-956.e912 (2014). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 430.5 |
| 分子式 | C25H34O6 |
| CAS号 | 75567-37-2 |
| 稳定性 | ≥ 2 years |
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