| 货号 | 15121-5g |
| 描述 | Ursodeoxycholic acid (UDCA) is a hydrophilic bile acid best known for its role in cholesterol gallstone dissolution and the treatment of several liver diseases, including primary biliary cirrhosis.1 It interferes with the transport activity of the sodium taurocholate cotransporting polypeptide with an IC50 value of 3.6 μM.2,3 UDCA also inhibits apoptosis in liver cells by preventing formation of reactive oxygen species and the translocation of the pro-apoptotic protein Bax from the cytosol to the mitochondria.4 |
| 别名 | UDCA; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Jackson, H.,Solaymani-Dodaran, M.,Card, T.R., et al. Influence of ursodeoxycholic acid on the mortality and malignancy associated with primary biliary cirrhosis: A population-based cohort study. Hepatology 43(4), 1131-1137 (2007). 2.Kim, R.B.,Leake, B.,Cvetkovic, M., et al. Modulation by drugs of human hepatic sodium-dependent bile acid transporter (sodium taurocholate cotransporting polypeptide) activity. Journal of Pharmacology and Experimental Therapeutics 291(3), 1204-1209 (1999). 3.Craddock, A.L.,Love, M.W.,Daniel, R.W., et al. Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. American Journal of Physiology 274(1.1), G157-G169 (1998). 4.Amaral, J.D.,Viana, R.J.S.,Ramalho, R.M., et al. Bile acids: Regulation of apoptosis by ursodeoxycholic acid. Journal of Lipid Research 50(9), 1721-1734 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 414.6 |
| 分子式 | C24H39O4 • Na |
| CAS号 | 2898-95-5 |
| 稳定性 | ≥ 2 years |
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