| 货号 | 9002357-25mg |
| 描述 | L-Canaline is an aminooxy analog of ornithine that irreversibly inhibits aminotransferases (transaminases), including ornithine aminotransferase (Ki = 2 µM).1,2,3 It forms oximes with α-keto acids and aldehydes, most notably with pyridoxal phosphate, an essential cofactor of aminotransferases.3 L-Canaline is naturally found in plants, including legumes, and is involved in the metabolism of L-canavanine, an aminooxy analog of arginine.4 It is cytotoxic to a range of organisms, including bacteria, insects, and parasites.2,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bolkenius, F.N.,Knödgen, B. and Seiler, N. DL-Canaline and 5-fluoromethylornithine. Comparison of two inactivators of ornithine aminotransferase. Biochemistry Journal 268, 409-414 (1990). 2.Heilbronn, J.,Wilson, J. and Berger, B.J. Tyrosine aminotransferase catalyzes the final step of methionine recycling in Klebsiella pneumoniae. Journal of Bacteriology 181(6), 1739-1747 (1999). 3.Worthen, D.R.,Ratliff, D.K.,Rosenthal, G.A., et al. Structure-activity studies of L-canaline-mediated inhibition of porcinealanine aminotransferase. Chemical Research in Toxicology 9(8), 1293-1297 (1996). 4.Rosenthal, G.A. L-Canavanine Transport and Utilization in Developing Jack Bean, Canavalia ensiformis (L.) DC. [Leguminosae]. Plant Physiology 69, 1066-1069 (1982). 5.Berger, B.J. Antimalarial activities of aminooxy compounds. Antimicrobial Agents and Chemotherapy 44(9), 2540-2542 (2000). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 134.1 |
| 分子式 | C4H10N2O3 |
| CAS号 | 496-93-5 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |