EPZ020411
货号：
19160-25mg 基本售价：
9072.0 元 规格：
25 mg
产品信息
概述| 货号 | 19160-25mg |
| 描述 | EPZ020411 is an inhibitor of protein arginine methyltranferase 6 (PRMT6; IC50 = 10 nM) that less potently targets PRMT1 and PRMT8 (IC50s = 119 and 223 nM, respectively).1 It dose-dependently decreases methylation of the PRMT6 substrate H3R2 in A375 cells transiently expressing PRMT6 (IC50 = 0.637 µM).1 EPZ020411 shows a moderate clearance rate in rats following intravenous bolus administration, and, following 5 mg/kg subcutaneous dosing, has an unbound blood concentration exceeding the PRMT6 biochemical IC50 value for more than 12 hours.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mitchell, L.H.,Drew, A.E.,Ribich, S.A., et al. Aryl pyrazoles as potent inhibitors of arginine methyltransferases: Identification of the first PRMT6 tool compound. ACS Med. Chem. Lett. 6, 655-659 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 442.6 |
| 分子式 | C25H38N4O3 |
| CAS号 | 1700663-41-7 |
| 稳定性 | ≥ 2 years |
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