(S)-Crizotinib ( )
货号：
6025/50 基本售价：
9061.8 元 规格：
50 mg
产品信息
概述| 货号 | 6025/50 |
| 别名 | 3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine |
性能| 供应商 | Tocris |
| 生物活性 | Potent MTH1 inhibitor (IC50 = 72 nM). Induces DNA damage and disrupts nucleotide pool homeostasis in cancer cells. Also attenuates colony formation of KRAS-mutated PANC1 cells in vitro. Suppresses tumor growth ~50% in a colon cancer carcinoma xenograft model. |
| 运输条件 | Ambient |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 450.34 |
| 分子式 | C21H22Cl2FN5 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 20 mM in 1eq. HCl with gentle warming |
| 参考文献 | Huberet al (2014) Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Nature 508 222. PMID: 24695225. |
