| 货号 | 5791/50 |
| 别名 | 7-Chloro-1,3-dihydro-5-(4-hydroxyph |
| 供应商 | Tocris |
| 生物活性 | ATP synthase inhibitor (IC50~5μM). Binds the oligomycin sensitivity conferring protein (OSCP) component of mitochondrial F1F0-ATPasein vitro resulting in generation of superoxide and apoptosis. Kills primary B and T cell in mice in vivo. Suppresses autoimmunity and prolongs survival in mouse lupus model. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 440.92 |
| 分子式 | C27H21ClN2O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Blattet al (2009) Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax. Biochem.Pharmacol. 15 966. PMID: 19481066. Johnsonet al (2005) Identification and validation of the mitochondrial F1F0-ATPase as the molecular target of the immunomodulatory benzodiazepine Bz-423. Chem.Biol. 12 485. PMID: 15850986. Blattet al (2002) Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility. J.Clin.Invest. 110 1123. PMID: 12393848. |