TC-E 5008 ( )
货号：
5244/50 基本售价：
9061.8 元 规格：
50 mg
产品信息
概述| 货号 | 5244/50 |
| 别名 | 1-Hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone |
性能| 供应商 | Tocris |
| 生物活性 | Selective mutant isocitrate dehydrogenase 1 (mIDH1) inhibitor (Ki = 120-190 nM). Displays >60-fold selectivity for mIDH1 (found in ~75% of gliomas) over wild type IDH1. Also inhibits D-2-hydroxyglutaric acid in cells expressing mIDH1 (EC50 = 2.4 μM). Does not display cytotoxicity towards non-cancerous human cells. Phenotypically lethal. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 215.25 |
| 分子式 | C13H13NO2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Zhenget al (2013) Crystallographic investigation and selective inhibition of mutant isocitrate dehydrogenase. ACS Med.Chem.Lett. 4 542. PMID: 23795241. |
