| 货号 | 17716-5mg |
| 描述 | 1,25-Dihydroxy vitamin D2 (Item No. 11174) is a potent agonist of the vitamin D receptor.1,2 Paricalcitol is a synthetic 1,25-dihydroxy vitamin D2 analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction.3,4,5 Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well.6 |
| 别名 | 1α,25-Dihydroxy-19-nor-vitamin D2;19-nor-1,25-Dihydroxyvitamin D2;Zemplar; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sudsakorn, S.,Phatarphekar, A.,OShea, T., et al. Determination of 1,25-dihydroxyvitamin D2 in rat serum using liquid chromatography with tandem mass spectrometry. Journal of Chromatography B 879, 139-145 (2011). 2.Kato, S.,Kim, M.S.,Yamaoka, K., et al. Mechanisms of transcriptional repression by 1,25(OH)2 vitamin D. Current Opinion in Nephrology and Hypertension 16, 297-304 (2007). 3.Brown, A.J.,Finch, J.,Takahashi, F., et al. Calcemic activity of 19-nor-1,25(OH)2D2 decreases with duration of treatment. Journal of the American Society of Nephrology 11, 2088-2094 (2000). 4.Donate-Correa, J.,Domínguez-Pimentel, V.,Muros-de-Fuentes, M., et al. Beneficial effects of selective vitamin D receptor activation by paricalcitol in chronic kidney disease. Current Drug Targets 15, 703-709 (2014). 5.Walf, M., and Thadhani, R. Vitamin D in patients with renal failure: A summary of observational mortality studies and steps moving forward. Journal of Steroid Biochemistry and Molecular Biology 103(3-5), 487-490 (2007). 6.Duplancic, D.,Cesarik, M.,Poljak, N.K., et al. The influence of selective vitamin D receptor activator paricalcitol on cardiovascular system and cardiorenal protection. Clinical Interventions in Aging 8, 149-156 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 416.6 |
| 分子式 | C27H44O3 |
| CAS号 | 131918-61-1 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |