SCH 51344
货号：
17804-50mg 基本售价：
8932.0 元 规格：
50 mg
产品信息
概述| 货号 | 17804-50mg |
| 描述 | SCH 51344 is a pyrazolo-quinoline derivative that inhibits Ras-induced malignant transformation and prevents anchorage-independent growth of oncogene transformed fibroblasts.1 At 5-25 µM, it has been shown to dose-dependently block Ras/Rac-induced membrane ruffling in REF-52 fibroblasts with little effect on Ras-induced ERK and JNK kinase activity.2 SCH 51344 is also reported to be a potent inhibitor of human mutT homolog MTH1, a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (Kd = 49 nM).3 |
| 别名 | Ras/Rac Transformaton Blocker; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kumar, C.C.,Prorock-Rogers, C.,Kelly, J., et al. SCH 51344 inhibits ras transformation by a novel mechanism. Cancer Research 55(21), 5106-5117 (1995).
2.Walsh, A.B.,Dhanasekaran, M.,Bar-Sagi, D., et al. SCH 51344-induced reversal of RAS-transformation is accompanied by the specific inhibition of the RAS and RAC-dependent cell morphology pathway. Oncogene 15(21), 2553-2560 (1997).
3.Huber, K.V.M.,Salah, E.,Branka, R., et al. Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Nature 508(7495), 222-227 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 316.4 |
| 分子式 | C16H20N4O3 |
| CAS号 | 171927-40-5 |
| 稳定性 | ≥ 2 years |
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