| 货号 | 10057-50mg |
| 描述 | Soluble guanylate cyclase (sGC), a receptor for nitric oxide (NO), is a heterodimer consisting of alpha and beta subunits, with the beta subunit featuring a heme-nitric oxide (H-NOX) binding domain.1 The binding of NO to H-NOX induces sGC to generate the second messenger cGMP. BAY 41-2272 is a pyrazolopyridine compound that acts as an activator of sGC, stimulating activity to a level that would be expected to cause biologically important increases in cGMP at concentrations as low as 10-100 nM.2 Through this effect, it inhibits platelet aggregation (IC50 = 36 nM), induces relaxation of phenylephrine-preconstricted rabbit aorta rings (IC50 = 304 nM), and reduces proliferation in smooth muscle.2,3 BAY 41-2272 is effective in vivo, as it decreases mean arterial blood pressure in hypertensive rats.2 Unlike another sGC activator, YC-1 (Item No. 81560), BAY 41-2772 does not inhibit phosphodiesterases.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Derbyshire, E.R., and Marletta, M.A. Structure and regulation of soluble guanylate cyclase. Annual Reviews of Biochemistry 81, 533-559 (2012). 2.Stasch, J.P.,Becker, E.M.,Alonso-Alija, C., et al. NO-independent regulatory site on soluble guanylate cyclase. Nature 410, 212-215 (2001). 3.Evgenov, O.V.,Pacher, P.,Schmidt, P.M., et al. NO-independent stimulators and activators of soluble guanylate cyclase: Discovery and therapeutic potential. Nature Reviews.Drug Discovery 5(9), 755-768 (2006). 4.Stasch, J.P.,Alonso-Alija, C.,Apeler, H., et al. Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: In vitro studies. British Journal of Pharmacology 135, 333-343 (2002). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 360.4 |
| 分子式 | C20H17FN6 |
| CAS号 | 256376-24-6 |
| 稳定性 | ≥ 2 years |
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