Steviol
货号：
10011344-50mg 基本售价：
8932.0 元 规格：
50 mg
产品信息
概述| 货号 | 10011344-50mg |
| 描述 | Steviol is the aglycon derivative of steviol glycosides, which are natural sweeteners isolated from S. rebaudiana. Steviol inhibits human organic anion transporters (hOATs) in uptake assays using murine cells from the S2 segment of proximal tubules. It is selective for hOAT1 and hOAT3 over hOAT2 and hOAT4 (IC50s = 11.4, 36.5, 1,000, and 285 μM, respectively).1 Uptake assays in mouse renal cortical slices yield similar results with IC50 values of 12.8 and 67.6 μM for hOAT1 and hOAT3, respectively.1 Due to the use of steviol glycosides as sweeteners, the safety of steviol is widely studied, including its genotoxicity and toxicokinetics.2,3 |
| 别名 | Hydroxy Dehydrostevic Acid;NSC 226902; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Srimaroeng, C.,Jutabha, P.,Pritchard, J.B., et al. Interactions of stevioside and steviol with renal organic anion transporters in S2 cells and mouse renal cortical slices. Pharm Res. 22(6), 858-866 (2005).
2.Brusick, D.J. A critical review of the genetic toxicity of steviol and steviol glycosides. Food Chem. Toxicol. 46(Suppl 7), S83-S91 (2008).
3.Roberts, A., and Renwick, A.G. Comparative toxicokinetics and metabolism of rebaudioside A, stevioside, and steviol in rats. Food Chem. Toxicol. 46(Suppl 7), S31-S39 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 318.5 |
| 分子式 | C20H30O3 |
| CAS号 | 471-80-7 |
| 稳定性 | ≥ 2 years |
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