| 货号 | 15386-2.5mg |
| 描述 | Ikarugamycin is a macrocyclic antibiotic first isolated from Streptomyces sp. that demonstrates potent antiprotozoal activity.1 It exhibits cytotoxic effects in cancer cell lines, inhibiting cell proliferation (IC50 = 221.3 nM in HL-60 cells) through genotoxicity and by inducing apoptosis and activation of caspases.2 It also was shown to significantly inhibit oxidized low-density lipoprotein-induced accumulation of cholesteryl esters in macrophages at 1-4 μM.3 Additionally, ikarugamycin is used to inhibit clathrin-coated pit-mediated endocytosis.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Jomon, K.,Kuroda, Y.,Ajisaka, M., et al. A new antibiotic, ikarugamycin. J.Antibiot.(Tokyo) 25(5), 271-280 (1972). 2.Popescu, R.,Heiss, E.H.,Ferk, F., et al. Ikarugamycin induces DNA damage, intracellular calcium increase, p38 MAP kinase activation and apoptosis in HL-60 human promyelocytic leukemia cells. Mutation Research 709-710, 60-66 (2011). 3.Hasumi, K.,Shinohara, C.,Naganuma, S., et al. Inhibition of the uptake of oxidized low-density lipoprotein in macrophage J774 by the antibiotic ikarugamycin. European Journal of Biochemistry 205(2), 841-846 (1992). 4.Luo, T.,Fredericksen, B.L.,Hasumi, K., et al. Human immunodeficiency virus type 1 Nef-induced CD4 cell surface downregulation is inhibited by ikarugamycin. Journal of Virology 75(5), 2488-2492 (2001). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 478.6 |
| 分子式 | C29H38N2O4 |
| CAS号 | 36531-78-9 |
| 稳定性 | ≥ 2 years |
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