| 货号 | 0464/50 |
| 别名 | N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5 |
| 供应商 | Tocris |
| 生物活性 | Selective vanilloid receptor antagonist (Ki = 3.2 μM). Inhibits carrageenan inflammation-induced hyperalgesic responses in the rat. Also activates amiloride-sensitive epithelial Na+ channel ENaCδ. Also available as part of the Vanilloid TRPV1 Receptor Tocriset™. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 376.9 |
| 分子式 | C19H21ClN2O2S |
| 可溶性/溶解性 | Soluble to 25 mM in ethanol and to 100 mM in DMSO |
| CAS号 | 138977-28-3 |
| 参考文献 | Yamamuraet al (2004) Capsazepine is a novel activator of the δ subunit of the human epithelial Na+ channel. J.Biol.Chem. 279 44483. PMID: 15308635. Kwaket al (1998) A capsaicin-receptor antagonist, capsazepine, reduces inflammation-induced hyperalgesic responses in the rat: evidence for an endogenous capsaicin-like substance. Neuroscience 86 619. PMID: 9881874. Dickenson and Dray (1991) Selective antagonism of capsaicin by capsazepine: evidence for a spinal receptor site in capsaicin-induced antinociception. Br.J.Pharmacol. 104 1045. PMID: 1810591. |