Chidamide
货号：
13686-25mg 基本售价：
8876.0 元 规格：
25 mg
产品信息
概述| 货号 | 13686-25mg |
| 描述 | Chidamide is a histone deacetylase inhibitor that increases histone H3 acetylation levels in LoVo and HT-29 colon cancer cells at concentrations as low as 4 µM.1 Additionally, chidamide affects the activation of oncogenic signaling kinases by dose-dependently reducing phosphorylated Akt, mTOR, p70S6k, Raf, and Erk1/2 protein expression in colon cancer cells.1 Furthermore, chidamide treatment dose-dependently upregulates p21 protein expression, downregulates Cdk4, and induces cell cycle arrest at the G0/G1phase.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Liu, L.,Chen, B.,Qin, S., et al. A novel histone deacetylase inhibitor Chidamide induces apoptosis of human colon cancer cells. Biochemical and Biophysical Research Communications 392, 190-195 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 390.4 |
| 分子式 | C22H19FN4O2 |
| CAS号 | 743420-02-2 |
| 稳定性 | ≥ 2 years |
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