UVI3003
货号：
16026-50mg 基本售价：
8848.0 元 规格：
50 mg
产品信息
概述| 货号 | 16026-50mg |
| 描述 | The receptors for retinoids, RARs and RXRs, form heterodimers with many other family members in order to control various physiological and pathological processes, including cancer and metabolic diseases. UVI3003 is a full antagonist of RXR that demonstrates potent, nanomolar binding affinity.1 At 1 µM, UVI3003 does not affect the corepressor interaction capacity of the RARα subunit in the RAR-RXR heterodimer configuration.1 This compound can be used to isolate the contribution of RXR to the function of RXR heterodimers.1,2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Nahoum, V.,Pérez, E.,Germain, P., et al. Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function. Proc. Natl. Acad. Sci. USA 104(44), 17323-17328 (2007).
2.le Maire, A.,Grimaldi, M.,Roecklin, D., et al. Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors. EMBO reports 10(4), 367-373 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 436.6 |
| 分子式 | C28H36O4 |
| CAS号 | 847239-17-2 |
| 稳定性 | ≥ 2 years |
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