15-deoxy-Δ12,14-Prostaglandin D2
货号：
12700-5mg 基本售价：
8848.0 元 规格：
5 mg
产品信息
概述| 货号 | 12700-5mg |
| 描述 | 15-deoxy-Δ12,14-PGD2 is a synthetic analog of PGD2 and a potential precursor to the PPARγ ligand 15-deoxy-Δ12,14-PGJ2.1 It possesses cytotoxic effects on L1210 mouse leukemia cells in vitro with an IC50 of 0.3 µg/ml. 15-deoxy-Δ12,14-PGD2 is 10-fold more potent than PGD2 in this activity.2 However, it is a less effective inhibitor of ADP-induced platelet aggregation (IC50 = 320 ng/ml) compared to PGD2(IC50 = 3 ng/ml).3 |
| 别名 | 15-deoxy-Δ12,14-PGD2; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Forman, B.M.,Tontonoz, P.,Chen, J., et al. 15-Deoxy-Δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83, 803-812 (1995).
2.Kato, T.,Fukushima, M.,Kurozumi, S., et al. Antitumor activity of Δ7-prostaglandin A1 and Δ12-prostaglandin J2 in vitro and in vivo. Cancer Research 46, 3538-3542 (1986).
3.Bundy, G.L.,Morton, D.R.,Peterson, D.C., et al. Synthesis and platelet aggregation inhibiting activity of prostaglandin D analogues. Journal of Medicinal Chemistry 26, 790-799 (1983).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 334.5 |
| 分子式 | C20H30O4 |
| CAS号 | 85235-11-6 |
| 稳定性 | ≥ 1 year |
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